Mohammadreza Sheikh Sajjadieh,
Volume 19, Issue 6 (11-2025)
Abstract
Pseudogout, or calcium pyrophosphate deposition disease, is a common but frequently underdiagnosed form of crystal-induced arthritis. It is characterized by the deposition of calcium pyrophosphate dihydrate crystals in joint cartilage and synovial fluid. Although the clinical presentation often mimics gout or septic arthritis, the underlying pathophysiology and crystal morphology differ significantly. This review highlights the crucial role of polarized light microscopy in the diagnosis of Pseudogout, particularly in differentiating it from other forms of arthritis. Polarized Light Microscopy is a valuable diagnostic tool that allows for the visualization and identification of rhomboid-shaped, weakly positively birefringent crystals. I discuss the principles of Polarized Light Microscopy, specimen handling, morphological features of crystals, and current laboratory practices, as well as the importance of technician training in enhancing diagnostic accuracy. By raising awareness and encouraging the standardized use of Polarized Light Microscopy, we aim to improve the detection and management of pseudogout in clinical laboratory settings.
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