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Showing 3 results for Mehrdad
Improvement of nurses’ clinical practice in neonatal pain management: A Protocol of Evidence-Based Intervention
Razieh Talebi, Mahnaz Modanloo, Fatemeh Heydari , Neda Mehrdad, Abbasali Keshtkar, Homeira Khoddam,
Volume 19, Issue 1 (1-2022)
Abstract
Background: Despite the expansion of knowledge of neonatal pain assessment and management, there is still a considerable gap between nurses' clinical practices in Iran and available evidence. The aim of this study was to develop an evidence-based protocol for neonatal pain management and to evaluate its effectiveness on nurses' clinical practice.
Methods: The present study will be based on the Johns Hopkins nursing evidence-based practice (JHNEBP) model and the three stages of practice question and project planning, evidence, and translation (PET). In this way, after forming an interprofessional team, clinical practice questions will be defined, and the main stakeholders will be identified. Then, the types, levels, and quality of evidence will be assessed to summarize their final strength using the proposed tools of the model, and finally, recommendations will be developed. In the translation phase, the recommendations will be implemented during a stepped wedge cluster randomized trial, and its implications for nursing practices in the management of pain in hospitalized neonates will be evaluated.
Results: The results of this study will lead to the production of an operational and applicable protocol in the management of pain in hospitalized neonates. It can provide the basis for improving the clinical practice of nurses and subsequently improving the quality of neonatal care.
Conclusion: One of the strengths of this study is the use of an interprofessional team approach, considering the clients' priorities, and the improvement of organizational culture in order to endeavor for knowledge translation and change in clinical practice.
 

Prevalence and risk factors associated with preterm births in Neyshabur hospitals, Eastern Iran
Mehrdad Rohaninasab, Masumeh Hesari, Zahra Mollazadeh Narestan , Akram Gazerani,
Volume 21, Issue 3 (10-2024)
Abstract
Background: The increasing prevalence of preterm birth in many societies has raised concerns. This study was conducted to determine the prevalence and risk factors associated with preterm birth in hospitals in Neyshabur, Eastern Iran.
Methods: This cross-sectional study was conducted on 273 neonates born before 37 weeks of gestational age between 2017 and 2019 in the educational hospitals of Neyshabur. The infants were included in the research through convenience sampling. The research tool consisted of items addressing issues related to both mothers and newborns. Data analysis was performed using SPSS version 22, employing descriptive and analytical statistics, including chi-square and Fisher's exact tests.
Results: The rate of preterm birth in Neyshabur over the three-year period was 2.85%. Bicornuate uterus (1.83%) and cervical insufficiency (1.46%) were the most observed uterine factors, while umbilical cord prolapse (1.83%) and placental adhesion (1.46%) were the most prevalent placental factors. Moreover, breech presentation (10.98%) was the most common co-occurring fetal factor in preterm birth. A significant difference was found between the length of pregnancy and the type of delivery (vaginal or cesarean section) (P=0.003).
Conclusion: Due to the high prevalence of preterm birth in Neyshabur, it is recommended that mothers undergo periodic evaluations before and during pregnancy to identify and manage any accompanying problems or underlying conditions promptly.
 

Effectiveness of cinnamol and chlorhexidine in treating oral mucositis in cancer patients: A Randomized Clinical Trial
Mohammad Siavoshi , Hossein Rahimi , Mehrdad Rohaninasab , Mostafa Motamedi Heravi , Fatemeh Khorashadizadeh, Mohammad Gholizadeh Gerdrodbari , Morteza Hasheminik ,
Volume 22, Issue 4 (12-2025)
Abstract
Background: Oral mucositis is a common complication of chemotherapy that significantly reduces patients' quality of life. While chlorhexidine mouthwash has been shown to improve oral mucositis, it can also cause side effects such as dysgeusia. In this context, simpler, plant-based alternatives like cinnamol may offer similar benefits without the associated side effects. This study aimed to compare the effectiveness of cinnamol mouthwash with that of chlorhexidine mouthwash in treating oral mucositis in cancer patients undergoing treatment with doxorubicin.
Methods: This randomized clinical trial included 81 patients with cancer (breast, ovarian, bladder, lung, and colorectal) from two hospitals in Neyshabur and Sabzevar cities, located in northeastern Iran, in 2023. Participants were allocated to the control (n=27), chlorhexidine (n=27), and cinnamol (n=27) groups using a block randomization method. The control group received 0.9% physiological saline; the chlorhexidine group used chlorhexidine mouthwash, and the cinnamol group used cinnamol mouthwash. Participants were instructed to mix 25 drops of their assigned solution with 50 mL of lukewarm water, gargle for 30 seconds, and then expel the mixture. The intervention was administered twice every 12 hours for 14 days. Data were collected using a demographic questionnaire and the Standard Mucositis Assessment Tool on the first, seventh, and fourteenth days of the intervention. Data analysis was performed using R software version 4.2.2, employing univariate tests and the cumulative link mixed-effects model (CLMM). Results were presented as odds ratios with 95% confidence intervals.
Results: Both cinnamol and chlorhexidine mouthwashes significantly reduced oral mucositis severity compared to the control group. The odds of more severe mucositis in patients using chlorhexidine were 0.0021 times the odds in the control group (OR = 0.0021, p<0.001), meaning a lower risk in the chlorhexidine group by a factor of about 1/0.0021 ≈ 476). Also, cinnamol administration significantly diminished the odds of severe mucositis (OR = 0.0005, p<0.001) compared to the control. Over time, the protective effects of chlorhexidine (OR = 0.024, p<0.001) and cinnamol (OR = 0.269, p=0.060) became more pronounced, indicating a progressive healing trajectory.
Conclusion: Cinnamol and chlorhexidine mouthwashes demonstrated significant efficacy in reducing oral mucositis severity, while chlorhexidine effects were more enhanced over time. These insights suggest that both interventions are valuable in managing oral mucositis, offering valuable guidance for nursing practice and patient care.

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