en Nursing Original Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Improving the success of peripheral intravenous catheterization (PIVC) requires developing students&#39; clinical self-confidence alongside their theoretical knowledge. This study aimed to examine the relationship between nursing students&#39; PIVC knowledge levels and their self-confidence.<br> <b>Methods:</b> This correlational study was conducted with nursing students enrolled at a university in T&uuml;rkiye. A total population sampling approach was used; of 359 eligible students invited, 253 agreed to participate. Data were collected face-to-face between January and April 2026 using a Demographic Data Form, the Peripheral Intravenous Catheter Insertion Knowledge Form, and the Peripheral Intravenous Catheter Insertion Self-Confidence Scale for Nursing Students. Data were analyzed using descriptive statistics, multiple linear regression, one-way ANOVA with Tukey HSD post-hoc tests, and Pearson correlation analysis in SPSS 23.<br> <b>Results:</b> Academic year, positive beliefs about catheter insertion ability, and experience performing PIVC under supervision in clinical practice were significant positive predictors of both total PIVC knowledge (R2 = 0.168, p < 0.001) and self-confidence scores (R2 = 0.323, p < 0.001). Statistically significant differences across academic years were found in total PIVC knowledge scores [F (3, 249) = 5.927, p = 0.001, &eta;&sup2; = 0.067] and total PIVC self-confidence scores [F (3, 249) = 9.435, p < 0.001, &eta;&sup2; = 0.102].&nbsp; A statistically significant, weak-to-moderate positive correlation was observed between the students&#39; total PIVC knowledge scores and total self-confidence scale scores (r=0.320, p< 0.001).<br> <b>Conclusion</b>: The findings indicated that as nursing students&#39; PIVC knowledge levels increased, their self-confidence also increased. To sustain knowledge over time and address technical skill gaps, refresher PIVC training should be integrated into the curriculum at each grade level and incorporate simulation-based training models that support motor skill acquisition into laboratory sessions.</span></span></div> Peripheral Catheterization, Nursing students, Knowledge, Self-confidence 0 0 http://nmj.goums.ac.ir/browse.php?a_code=A-10-2609-1&slc_lang=en&sid=1 Handan Eren erennhandan@gmail.com 0000-0002-6507-5690 Yes Department of Nursing, Faculty of Health Sciences, Yalova University, Yalova, Türkiye