en Psychology and Psychiatry Original Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> The families of patients with mental disorders can provide an appropriate foundation for care. This study aimed to determine the effect of the Family-Centered Empowerment Model on self-care requisites in patients with schizophrenia.<br> <b>Methods:</b> This randomized controlled trial, conducted in 2025, enrolled 72 patients with schizophrenia who were discharged from Razi Hospital, Tabriz, Iran, together with their primary caregivers. Eligible patients were randomly allocated to the intervention (n = 36) or control (n = 36) group using block randomization. Data were collected at baseline and after the intervention using the Self-Care Requisites Scale in Schizophrenia (SCRS-H). Caregivers in the intervention group participated in eight weekly group-based educational sessions based on the Family-Centered Empowerment Model, whereas the control group received routine care. Data were analyzed using independent t-tests and analysis of covariance (ANCOVA), with adjustment for baseline scores and educational level, using SPSS version 25.<br> <b>Results:</b> The two groups were comparable at baseline with respect to demographic and clinical characteristics. Following the intervention, the intervention group demonstrated significantly better self-care requisites (reduced SCRS-H score) than the control group (90.72 &plusmn; 12.19 vs. 100.22 &plusmn; 15.03, P = 0.004). After adjustment for baseline scores and educational level, ANCOVA confirmed a significant effect of the intervention (P < 0.001). The intervention had a moderate-to-large effect on self-care requisites (Cohen&#39;s d = 0.69, 95% CI: 0.21&ndash;1.17).<br> <b>Conclusion</b>: Participation in the Family-Centered Empowerment Model was associated with significant improvements in self-care requisites among patients with schizophrenia. This intervention may represent a useful adjunct to routine psychiatric rehabilitation by strengthening patients&#39; capacity for self-care. Further multicenter studies with larger samples and extended follow-up are warranted to confirm these findings and assess their long-term clinical impact.</span></span><br> &nbsp;</div> Self Care, Family-Centered Empowerment, Schizophrenia 0 0 http://nmj.goums.ac.ir/browse.php?a_code=A-10-2461-1&slc_lang=en&sid=1 Ali Taghavi Deghdeghdn alitaghavi69@iran.ir 100319475328460018253 100319475328460018253 No Department of Psychiatric Nursing, School of Nursing and Midwifery, Qazvin University of Medical Qazvin, Qazvin, Iran Mohammad Reza Sheikhi msheikhi@qums.ac.ir 100319475328460018254 100319475328460018254 Yes Department of Psychiatric Nursing, School of Nursing and Midwifery, Qazvin University of Medical Qazvin, Qazvin, Iran Maryam Vahidi maryamvahidi84@gmail.com 100319475328460018255 100319475328460018255 No Department of Psychiatric Nursing, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran Mehdi Ranjbaran mehdiranjbaran90@yahoo.com 100319475328460018256 100319475328460018256 No Non-communicable Diseases Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran